Title

Association between infection burden and adult height

Keywords

infection burden, adult height, biology economics

Abstract

Although highly heritable, adult height is also associated with numerous environmental factors, including exposure to infection. Particularly in developing regions of the world, infection burden appears to slow growth during childhood. Using a large database representative of the US population, we examined associations between adult height and leg length and an infection-burden index based on past exposure to Toxocara species, Toxoplasmosis gondii, cytomegalovirus, hepatitis A, hepatitis B, hepatitis C, herpes simplex virus 1, and herpes simplex virus 2. In models controlled for age, sex, educational attainment, socioeconomic status, and race-ethnicity, we found that the infection-burden index predicted height (β = −0.10 [95% CI: −0.15, −0.05], p .001<0.001) but not leg length (β = −0.04 [95% CI: −0.12, 0.04], p = 0.357). Both sex and race-ethnicity moderated this association. In addition, exposures to Toxocara species, cytomegalovirus, and hepatitis A were each individually associated with reduced height and reduced leg length. While associations between growth and infection have been found principally in children in developing regions of the world, our findings suggest that the effects of infection on height may persist into adulthood even in developed nations.

Original Publication Citation

Hedges, Dawson W., Andrew N. Berrett, Lance D. Erickson, Bruce L. Brown, Shawn D. Gale. (2017). “Association between Infection Burden and Adult Height.” Economics and Human Biology. 27:275-280. DOI: 10.1016/j.ehb.2017.08.002.

Document Type

Peer-Reviewed Article

Publication Date

2017-11

Publisher

Economics and Human biology

Language

English

College

Family, Home, and Social Sciences

Department

Sociology

University Standing at Time of Publication

Associate Professor

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