Keywords
cell motion, stochastic model
Abstract
A force based model of cell migration is presented which gives new insight into the importance of the dynamics of cell binding to the substrate. The main features of the model are the focus on discrete attachment dynamics, the treatment of the cellular forces as springs, and an incorporation of the stochastic nature of the attachment sites. One goal of the model is to capture the effect of the random binding and unbinding of cell attachments on global cell motion. Simulations reveal one of the most important factor influencing cell speed is the duration of the attachment to the substrate. The model captures the correct velocity and force relationships for several cell types.
Original Publication Citation
Journal of Biomechanical Engineering 135(7):71008. (2013) doi: 10.1115/1.4023987
BYU ScholarsArchive Citation
Dallon, J. C.; Scott, Matthew; and Smith, William V., "A Force Based Model of Individual Cell Migration with Discrete Attachment Sites and Random Switching Terms" (2013). Faculty Publications. 2719.
https://scholarsarchive.byu.edu/facpub/2719
Document Type
Peer-Reviewed Article
Publication Date
2013
Permanent URL
http://hdl.lib.byu.edu/1877/5545
Publisher
AMSE
Language
English
College
Physical and Mathematical Sciences
Department
Mathematics
Copyright Status
Copyright © 2013 by ASME
Copyright Use Information
http://lib.byu.edu/about/copyright/