Noise Analysis and Sensitivity Enhancement in Immunomagnetic Nanomechanical Biosensors
noise analysis, immunomagnetic nanomechanical biosensors
We report noise and detection limitations in cantilever-based immunomagnetic biosensors. A differential cantilever system with sensing and control arms was used whereby the control arm was passivated with bovine serum albumin (BSA) and the sensing arm was functionalized with biotin-BSA. Streptavidin-coated magnetic beads were exposed to cantilever arms. An oscillatory magnetic field induced a magnetic force on the beads which caused a relative deflection of the sensing arm. Increasing the excitation frequency suppressed the 1/f noise by 100-fold, resulting in a deflection resolution of 0.065Å in air.
Original Publication Citation
Icoz, Kutay and Iverson, Brian D. and Savran, Cagri. Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors. Applied Physics Letters, 93, 103902 (2008).
BYU ScholarsArchive Citation
Icoz, Kutay; Iverson, Brian D.; and Savran, Cagri, "Noise Analysis and Sensitivity Enhancement in Immunomagnetic Nanomechanical Biosensors" (2008). All Faculty Publications. 1588.
Applied Physics Letters
Ira A. Fulton College of Engineering and Technology
The publisher's final version can be accessed at http://scitation.aip.org/content/aip/journal/apl/93/10/10.1063/1.2980036.
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