Title

Thermodynamics of proton dissociation and metal ion complexation in aqueous solution.|nI.|pCation binding with cyclic polyethers: significance in ion transport processes.|nII.|pProton dissociation from adenosine, several monosaccharides and related compounds.|nIII.|pProton dissociation from several pyrimidines and their nucleosides at 10, 25 and 40°

Abstract

The log K, ΔH° and ΔS° values for the interaction of several metal ions with the two isomers of the cyclic polyether, 2,5,8,15,-18,21 hexaoxatricyclo[20.4.0.0^9,14]hexacosane are reported. The stability order found for alkali metal ion interaction with either isomer is identical to the order of ion permeability through reconstituted biological membranes for structurally related antibiotics. The size of the metal ion is critical in determining the extent of interaction. A calorimetric titration study of proton ionization from several monosaccharides and derivatives, pyrimidine bases and their nucleosides, adenosine and its derivatives, and cycloheptaamylose is described. The heats of reaction obtained in this study show the acidity of adenosine to be associated with the ribose portion of the molecule and that the presence of both the 2' and 3'-hydroxyl groups results in a marked acidity increase compared to similar compounds lacking vicinal OH groups. The acidity in the sugars is associated with the 1 position.

Degree

PhD

College and Department

Chemistry and Biochemistry

Rights

http://lib.byu.edu/about/copyright/

Date Submitted

1969-08-01

Document Type

Dissertation

Handle

http://hdl.lib.byu.edu/1877/Letd654

Keywords

Protons, Dissociation, Metal ions, Solution (Chemistry)

Language

English

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