Abstract

Thiamine deficiency has been reported to cause nerve degeneration in the peripheral nervous system and hemorrhage with associated cellular damage in the central nervous system (Prickett, 1934). Koedam (1958) observed convulsions in thiamine-deficient pigeons, but convulsions have only rarely been seen in rats (Gubler, 1961). Rats treated with the thiamine antagonist, pyrithiamine (PTh)* always develop ataxia and convulsions but these neurological symptoms have never been reported in those treated with oxythiamine (OTh), another thiamine antagonist (Gubler, 1961). Hosein, Chabrol, and Freedman (1966) concluded that neurological symptoms occur only when the brain thiamine content is diminished to 2.5%o r less of the normal values. This conclusion was supported by the work of others (DaCaro, tl ,al., 1956; and Cerecedo and Eich, 1955).

Degree

MS

College and Department

Plant and Wildlife Sciences

Rights

http://lib.byu.edu/about/copyright/

Date Submitted

1968-05-01

Document Type

Thesis

Handle

http://hdl.lib.byu.edu/1877/Letd142

Keywords

Vitamin therapy; Acetycholine; Vitamins; Metabolism

Language

English

Included in

Life Sciences Commons

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