Thiamine deficiency has been reported to cause nerve degeneration in the peripheral nervous system and hemorrhage with associated cellular damage in the central nervous system (Prickett, 1934). Koedam (1958) observed convulsions in thiamine-deficient pigeons, but convulsions have only rarely been seen in rats (Gubler, 1961). Rats treated with the thiamine antagonist, pyrithiamine (PTh)* always develop ataxia and convulsions but these neurological symptoms have never been reported in those treated with oxythiamine (OTh), another thiamine antagonist (Gubler, 1961). Hosein, Chabrol, and Freedman (1966) concluded that neurological symptoms occur only when the brain thiamine content is diminished to 2.5%o r less of the normal values. This conclusion was supported by the work of others (DaCaro, tl ,al., 1956; and Cerecedo and Eich, 1955).
College and Department
Plant and Wildlife Sciences
BYU ScholarsArchive Citation
Cheney, Darwin Leroy, "Studies on the levels of acetylcholine in the brains of thiamine-deprived and thiamine-antagonized rats" (1968). Theses and Dissertations. 7656.
Vitamin therapy; Acetycholine; Vitamins; Metabolism