Abstract
Thiamine deficiency has been reported to cause nerve degeneration in the peripheral nervous system and hemorrhage with associated cellular damage in the central nervous system (Prickett, 1934). Koedam (1958) observed convulsions in thiamine-deficient pigeons, but convulsions have only rarely been seen in rats (Gubler, 1961). Rats treated with the thiamine antagonist, pyrithiamine (PTh)* always develop ataxia and convulsions but these neurological symptoms have never been reported in those treated with oxythiamine (OTh), another thiamine antagonist (Gubler, 1961). Hosein, Chabrol, and Freedman (1966) concluded that neurological symptoms occur only when the brain thiamine content is diminished to 2.5%o r less of the normal values. This conclusion was supported by the work of others (DaCaro, tl ,al., 1956; and Cerecedo and Eich, 1955).
Degree
MS
College and Department
Life Sciences; Plant and Wildlife Sciences
Rights
http://lib.byu.edu/about/copyright/
BYU ScholarsArchive Citation
Cheney, Darwin Leroy, "Studies on the levels of acetylcholine in the brains of thiamine-deprived and thiamine-antagonized rats" (1968). Theses and Dissertations. 7656.
https://scholarsarchive.byu.edu/etd/7656
Date Submitted
1968-05-01
Document Type
Thesis
Handle
http://hdl.lib.byu.edu/1877/Letd142
Keywords
Vitamin therapy; Acetycholine; Vitamins; Metabolism
Language
English