Aquaporin-4 (AQP4) is a key component in maintaining proper glymphatic flow. In recent years, the glymphatic system has been discovered and approached as a major factor in amyloid plaque clearance in Alzheimer's disease. This study examines the depolarization of AQP4 from the astrocytic endfeet and subsequent co-localization with amyloid plaques in the hippocampus and subiculum. Results show a significant pattern of co-localization in advanced Alzheimer's disease, as well as increases in AQP4 in cerebrovascular disease. This pattern shows AQP4 should be approached as a promising therapeutic area in future research.
College and Department
Life Sciences; Neuroscience
BYU ScholarsArchive Citation
Crum, Anthony Bryan, "Co-Localization Patterns of Aquaporin-4 with Amyloid Beta and CD68 in Alzheimer's Disease and Cerebrovascular Disease" (2017). Theses and Dissertations. 7441.
aqp4, alzheimer's, co-localization, cerebrovascular, dementia