Abstract

Aquaporin-4 (AQP4) is a key component in maintaining proper glymphatic flow. In recent years, the glymphatic system has been discovered and approached as a major factor in amyloid plaque clearance in Alzheimer's disease. This study examines the depolarization of AQP4 from the astrocytic endfeet and subsequent co-localization with amyloid plaques in the hippocampus and subiculum. Results show a significant pattern of co-localization in advanced Alzheimer's disease, as well as increases in AQP4 in cerebrovascular disease. This pattern shows AQP4 should be approached as a promising therapeutic area in future research.

Degree

MS

College and Department

Neuroscience

Rights

http://lib.byu.edu/about/copyright/

Date Submitted

2017-07-01

Document Type

Thesis

Handle

http://hdl.lib.byu.edu/1877/etd10793

Keywords

aqp4, alzheimer's, co-localization, cerebrovascular, dementia

Language

english

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