Determining if c-Fos Regulates Glucose Stimulated Insulin

Authors

Benjamin Bitner, Brigham Young University
Jeffery Tessem, Brigham Young University

Keywords

c-Fos, glucose, stimulated insulin

College

Life Sciences

Department

Nutrition, Dietetics, and Food Science

Abstract

Increasing a patient’s functional β-cell mass may provide a cure for both types of diabetes. Previous studies have shown that overexpression of the homeodomain transcription factor Nkx6.1 stimulates β-cell proliferation, increases glucose stimulated insulin secretion (GSIS) and decreases apoptosis¹. Functional β-cell mass is defined by the number of β-cells, which is dependent on proliferation and apoptosis rates, multiplied by the ability to secrete insulin. Increasing β-cell proliferation or insulin secretion while decreasing apoptosis could be used as a treatment to produce β-cells for islet transplantation, a potential cure for diabetes.

Recommended Citation

Bitner, Benjamin and Tessem, Jeffery (2016) "Determining if c-Fos Regulates Glucose Stimulated Insulin," Journal of Undergraduate Research: Vol. 2016: Iss. 1, Article 172.
Available at: https://scholarsarchive.byu.edu/jur/vol2016/iss1/172