Keywords

drug delivery, tumor growth, chemotherapy, doxorubicin

Abstract

Previously we have shown that nanosized drug carriers called Plurogels™ sequestered Doxorubicin (Dox) and partially released this drug with application of ultrasound (US) (Fig. 1)1. The application to chemotherapy was successfully demonstrated in a rat tumor model2. However previous studies did not examine the distribution of Dox in the insonated and control tissue. This recent work investigated the effect of two US frequencies and examined the Dox distribution in the insonated and control tumors to determine if US was depositing more Dox at the insonated site.

Original Publication Citation

Staples, B.J., Pitt, W.G., Schaalje, J.B. and Roeder, B.L., "Ultrasonically-Assisted Drug Delivery in Rats Reduces Tumor Growth", Annual Meeting of the Controlled Release Society, 34, 839, Long Beach, CA, July 7-11, 27