alignment, gap penalties
Fundamental to multiple sequence alignment algorithms is modeling insertions and deletions (gaps). The most prevalent model is to use gap open and gap extension penalties. While gap open and gap extension penalties are well understood conceptually, their effects on multiple sequence alignment, and consequently on phylogeny scores are not as well understood. We use exhaustive phylogeny searching to explore the effects of varying the gap open and gap extension penalties for three nuclear ribosomal data sets. Particular attention is given to optimal phylogeny scores for 200 alignments of a range of gap open and gap extension penalties and their respective distribution of phylogeny scores.
Original Publication Citation
Effects of Gap Open and Gap Extension Penalties, Hyrum Carroll, Perry Ridge, Mark Clement, Quinn Snell, Biotechnology and Bioinformatics Symposium (BIOT), Provo, Utah, October 26, pp 19.
BYU ScholarsArchive Citation
Carroll, Hyrum; Clement, Mark J.; Ridge, Perry; and Snell, Quinn O., "Effects of Gap Open and Gap Extension Penalties" (2006). All Faculty Publications. 290.
Physical and Mathematical Sciences
© 2006 Quinn Snell et al.
Copyright Use Information