Title

Noise Analysis and Sensitivity Enhancement in Immunomagnetic Nanomechanical Biosensors

Keywords

noise analysis, immunomagnetic nanomechanical biosensors

Abstract

We report noise and detection limitations in cantilever-based immunomagnetic biosensors. A differential cantilever system with sensing and control arms was used whereby the control arm was passivated with bovine serum albumin (BSA) and the sensing arm was functionalized with biotin-BSA. Streptavidin-coated magnetic beads were exposed to cantilever arms. An oscillatory magnetic field induced a magnetic force on the beads which caused a relative deflection of the sensing arm. Increasing the excitation frequency suppressed the 1/f noise by 100-fold, resulting in a deflection resolution of 0.065Å in air.

Original Publication Citation

Icoz, Kutay and Iverson, Brian D. and Savran, Cagri. Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors. Applied Physics Letters, 93, 103902 (2008).

Document Type

Peer-Reviewed Article

Publication Date

2008

Permanent URL

http://hdl.lib.byu.edu/1877/3504

Publisher

Applied Physics Letters

Language

English

College

Ira A. Fulton College of Engineering and Technology

Department

Mechanical Engineering