anti-inflammatory drugs, Acetaminophen, Cyclooxygenase 2, fever, NSAIDs, COX-2
Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used antipyretic agents that most probably exert their antifever effect by inhibiting cyclooxygenase (COX)–2. Thus, COX-2–selective drugs or null mutation of the COX-2 gene reduce or prevent fever. Acetaminophen is antipyretic and analgesic, as are NSAIDs, but it lacks the anti-inflammatory and anticoagulatory properties of these drugs. This has led to the speculation that a COX variant exists that is inhibitable by acetaminophen. An acetaminophen-inhibitable enzyme is inducible in the mouse J774.2 monocyte cell line. Induction of acetaminophen-inhibitable prostaglandin E2 synthesis parallels induction of COX-2. Thus, inhibition of pharmacologically distinct COX-2 enzyme activity by acetaminophen may be the mechanism of action of this important antipyretic drug.
Original Publication Citation
Clinical Infectious Diseases 31.s5(Oct 2): S211-S218.
BYU ScholarsArchive Citation
Simmons, Daniel L.; Wagner, David; and Westover, Kenneth, "Nonsteroidal Anti-Inflammatory Drugs, Acetaminophen, Cyclooxygenase 2, and Fever" (2000). All Faculty Publications. 1220.
University of Chicago Press
Physical and Mathematical Sciences
Chemistry and Biochemistry
© 2000 by the Infectious Diseases Society of America.
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