Chimeric Antigen Receptor (CARs) for Thymidine Kinase 1 (TK1): A novel immunotherapy approach to fight cancer.

Edwin Jesus Velazquez, Brigham Young University - Provo
Kiara Vaden, Brigham Young University - Provo
Michelle H. Townsend, Brigham Young University - Provo
Evita G. Weagel, Brigham Young University - Provo
Scott Weber, Brigham Young University - Provo
Richard A. Robison, Brigham Young University - Provo
Kim L. O'Neill, Brigham Young University - Provo

Description

We have found the expression of Thymidine Kinase 1 (TK1) on the cell membrane of multiple cancer cell lines. We propose TK1 as a novel potential target for immune cell recognition in different cancer cell lines. Our research explores the use of these new targets in Chimeric antigen receptor (CAR) T-cell therapy.

 

Chimeric Antigen Receptor (CARs) for Thymidine Kinase 1 (TK1): A novel immunotherapy approach to fight cancer.

We have found the expression of Thymidine Kinase 1 (TK1) on the cell membrane of multiple cancer cell lines. We propose TK1 as a novel potential target for immune cell recognition in different cancer cell lines. Our research explores the use of these new targets in Chimeric antigen receptor (CAR) T-cell therapy.